pI: 9.2068 |
Length (AA): 482 |
MW (Da): 53663 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127994)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G21710 | 8-oxoguanine-DNA glycosylase 1 |
Babesia bovis | BBOV_I004290 | 8-oxoguanine DNA glycosylase, putative |
Brugia malayi | Bm1_04400 | Helix-hairpin-helix motif family protein |
Candida albicans | CaO19_7190 | hypothetical protein |
Candida albicans | CaO19.7190 | 8-oxo-guanine DNA glycosylase |
Cryptosporidium hominis | Chro.80237 | ENSANGP00000020191 |
Cryptosporidium parvum | cgd8_2020 | OGG1 like 8-oxoguanine DNA glycosylase involved in DNA repair |
Dictyostelium discoideum | DDB_G0292618 | 8-oxoguanine DNA-glycosylase |
Drosophila melanogaster | Dmel_CG1795 | CG1795 gene product from transcript CG1795-RA |
Echinococcus granulosus | EgrG_001062100 | N glycosylase:DNA lyase |
Echinococcus multilocularis | EmuJ_001062100 | N glycosylase:DNA lyase |
Homo sapiens | ENSG00000114026 | 8-oxoguanine DNA glycosylase |
Leishmania braziliensis | LbrM.20.1670 | 8-oxoguanine DNA glycosylase, putative |
Leishmania donovani | LdBPK_341930.1 | 8-oxoguanine DNA glycosylase, putative |
Leishmania infantum | LinJ.34.1930 | 8-oxoguanine DNA glycosylase, putative |
Leishmania major | LmjF.34.2170 | 8-oxoguanine DNA glycosylase, putative |
Leishmania mexicana | LmxM.33.2170 | 8-oxoguanine DNA glycosylase, putative |
Loa Loa (eye worm) | LOAG_12878 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10615 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12877 | hypothetical protein |
Mus musculus | ENSMUSG00000030271 | 8-oxoguanine DNA-glycosylase 1 |
Neospora caninum | NCLIV_001760 | N-glycosylase/DNA lyase, putative |
Oryza sativa | 4329639 | Os02g0552600 |
Plasmodium berghei | PBANKA_0818100 | N-glycosylase/DNA lyase, putative |
Plasmodium falciparum | PF3D7_0917100 | N-glycosylase/DNA lyase, putative |
Plasmodium knowlesi | PKNH_0715100 | N-glycosylase/DNA lyase, putative |
Plasmodium vivax | PVX_099275 | N-glycosylase/DNA lyase, putative |
Plasmodium yoelii | PY07176 | OGG1 protein type 2e-related |
Saccharomyces cerevisiae | YML060W | 8-oxoguanine glycosylase OGG1 |
Schistosoma japonicum | Sjp_0080960 | ko:K03660 N-glycosylase/DNA lyase, putative |
Schistosoma mansoni | Smp_192930 | hypothetical protein |
Schistosoma mansoni | Smp_074010.1 | 8-oxoguanine DNA glycosylase |
Schistosoma mansoni | Smp_074010.2 | 8-oxoguanine DNA glycosylase |
Schmidtea mediterranea | mk4.010071.00 | |
Schmidtea mediterranea | mk4.010167.00 | |
Trypanosoma brucei gambiense | Tbg972.4.2440 | 8-oxoguanine DNA glycosylase, putative |
Trypanosoma brucei | Tb927.4.2480 | 8-oxoguanine DNA glycosylase, putative |
Trypanosoma congolense | TcIL3000_4_2360 | 8-oxoguanine DNA glycosylase, putative |
Trypanosoma cruzi | TcCLB.506559.170 | 8-oxoguanine DNA glycosylase, putative |
Trypanosoma cruzi | TcCLB.510229.20 | 8-oxoguanine DNA glycosylase, putative |
Toxoplasma gondii | TGME49_294880 | 8-oxoguanine DNA glycosylase, N-terminal domain-containing protein |
Theileria parva | TP01_0968 | 8-oxoguanine DNA-glycosylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.2480 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.2480 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.2480 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.4.2480 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_294880 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.